| Identification | Back Directory | [Name]
Lipoamide-PEG3-Mal | [CAS]
1314378-19-2 | [Synonyms]
LA-PEG3-NH-Mal
Lipoamide-PEG3-Mal
LIPOAMIDE-PEG3-NH-MAL
1H-Pyrrole-1-propanamide, N-[19-(1,2-dithiolan-3-yl)-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-2,5-dihydro-2,5-dioxo- | [Molecular Formula]
C25H41N3O7S2 | [MDL Number]
MFCD21363247 | [MOL File]
1314378-19-2.mol | [Molecular Weight]
559.74 |
| Hazard Information | Back Directory | [Description]
Lipoamide-PEG3-Mal contains a lipoic acid group and a terminal maleimide group. Lipoic acid contains two sulfur atoms (at C6 and C8) connected by a disulfide bond and is thus considered to be oxidized although either sulfur atom can exist in higher oxidation states. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG linker increases the water solubility of the compound. | [Uses]
Lipoamide-PEG3-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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