| Identification | Back Directory | [Name]
10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile | [CAS]
1309925-39-0 | [Synonyms]
Tubulin inhibitor 8
10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile
10H-Phenoxazine-3-carbonitrile, 10-(4-methoxybenzoyl)- | [Molecular Formula]
C21H14N2O3 | [MDL Number]
MFCD34470244 | [MOL File]
1309925-39-0.mol | [Molecular Weight]
342.35 |
| Hazard Information | Back Directory | [Uses]
Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1]. | [References]
[1] Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. DOI:10.1021/jm200436t |
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cjbscvictory
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