| Identification | Back Directory | [Name]
Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide | [CAS]
1269815-17-9 | [Synonyms]
Novartis
CDK-IN-2
CDK inhibitor 2
CDK inhibitor II
(R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide
(3R)-N-[5-Chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-3-piperidinecarboxamide
3-Piperidinecarboxamide, N-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (3R)-
Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C18H19ClFN3O2 | [MOL File]
1269815-17-9.mol | [Molecular Weight]
363.81 |
| Chemical Properties | Back Directory | [Boiling point ]
525.6±50.0 °C(Predicted) | [density ]
1.300 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
12.16±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4.
IC50 Value: <8 nM [1]
Target: CDK9
In vitro:
In vivo: | [IC 50]
CDK9/cyclinT1: 8 nM (IC50) | [References]
[1] Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1. |
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