| Hazard Information | Back Directory | [Uses]
KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1]. | [in vivo]
KHS101 (6 mg/kg; s.c.; BID for 14 days) distributes to the brain and significantly increases neuronal differentiation in rats in vivo[1]. | Animal Model: | Adult Fisher 344 rats (～10 wk old)[1] | | Dosage: | 6 mg/kg | | Administration: | SC, BID for 14 days | | Result: | Increased neuronal differentiation. Reduced proliferation of NPCs. |
| [References]
[1] Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. DOI:10.1073/pnas.1010300107 |
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