| Identification | Back Directory | [Name]
ASK1-IN-1 | [CAS]
1262041-49-5 | [Synonyms]
CS-2713
ASK IN 1
GS-444217
ASK1-IN-1
ASK1-IN-110
ASK1-IN-1/GS-444217
4-(4-cyclopropyl-1H-imidazol-1-yl)-N-(3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl)picolinamide
2-Pyridinecarboxamide, 4-(4-cyclopropyl-1H-imidazol-1-yl)-N-[3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl]- | [Molecular Formula]
C23H21N7O | [MOL File]
1262041-49-5.mol | [Molecular Weight]
411.46 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:37.75(Max Conc. mg/mL);91.74(Max Conc. mM) | [form ]
Solid | [pka]
11.20±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM[1]. | [in vivo]
GS-444217 reduces oxidative stress (OS)-induced ASK1 signaling in kidney and inhibits acute renal tubular injury in rats. GS-444217 (30 mg/kg) inhibits activation of ASK1, p38, and JNK in rat kidney. GS-444217 has an in vivo EC50 of approximately 1.6 μM for inhibiting the ASK1 pathway in rodent kidney[1]. | [References]
[1] Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney disease. J Clin Invest. 2018 Oct 1;128(10):4485-4500. DOI:10.1172/JCI99768
[2] Budas GR, et al. ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Feb 1;197(3):373-385. DOI:10.1164/rccm.201703-0502OC |
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| Company Name: |
Syntechem Co.,Ltd.
|
| Tel: |
519-88298820 15861130028 |
| Website: |
http://www.syntechem.com |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|