| Identification | Back Directory | [Name]
8-Allylthioguanosine | [CAS]
126092-30-6 | [Synonyms]
8-Allylthioguanosine
Guanosine, 8-(2-propenylthio)- (9CI) | [Molecular Formula]
C13H17N5O5S | [MOL File]
126092-30-6.mol | [Molecular Weight]
355.37 |
| Hazard Information | Back Directory | [Uses]
8-Allylthioguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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