| Identification | Back Directory | [Name]
1H-Indole-4,5,6,7-d4-3-carboxylic acid | [CAS]
1258955-93-9 | [Synonyms]
DolasetronImpurity5-d4
1H-Indole-4,5,6,7-d4-3-carboxylic acid
Dolasetron Impurity 5-d4 (Indole-3-Carboxylic Acid-d4) | [Molecular Formula]
C9H7NO2 | [MOL File]
1258955-93-9.mol | [Molecular Weight]
161.16 |
| Hazard Information | Back Directory | [Uses]
Indole-3-carboxylic acid-d4 is deuterium labeled Indole-3-carboxylic acid. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases[1][2][1][2][3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Byrd DJ, et al. The analysis of indolic tryptophan metabolites in human urine. Thin-layer chromatography and in situ quantitation. J Chromatogr. 1974 Jul 17;94(0):85-106. DOI:10.1016/s0021-9673(01)92359-3
[3] HARTMANN F, et al. [Indolepatterns in the urine of liver patients]. Klin Wochenschr. 1962 Jul 15;40:721-9. DOI:10.1007/BF01482411 |
|
|