| Identification | Back Directory | [Name]
TH1338 | [CAS]
1258494-60-8 | [Synonyms]
TH1338
TH-1318
TH 1338; TH-1338
7-ethyl-14-amino-camptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 5-amino-4,11-diethyl-4-hydroxy-, (4S)- | [Molecular Formula]
C22H21N3O4 | [MDL Number]
MFCD23381068 | [MOL File]
1258494-60-8.mol | [Molecular Weight]
391.42 |
| Chemical Properties | Back Directory | [Boiling point ]
721.7±60.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.08±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile[1][2]. | [References]
[1] Jian-Xin Duan, et al. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011 Mar 24;54(6):1715-23. DOI:10.1021/jm101354u
[2] Xia Cheng, et al. Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma. J Pharm Sci. 2015 Nov;104(11):3934-3942. DOI:10.1002/jps.24613 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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