| Identification | Back Directory | [Name]
INSULIN | [CAS]
12584-58-6 | [Synonyms]
INSULIN
insulin(dog)
insulin(pig)
insulinprocine
neutralinsulin
porcineinsulin
Insulin (Pork)
insulin,neutral
Insulin (swine)
insulin(spermwhale)
INSULIN HOG PANCREAS
Enzyme protectant HP
Insulin (porcine) CRS
Insulin, Zinc, Porcine
(100 mg) Insulin (Pork)
INSULIN PORCINE PANCREAS
insulin from hog pancreas
insulin from porcine pancreas
Insulin (Pork) (6.25 mg/ vial
fromporcinepancreasabout24i.u.mg
2 vials) (COLD SHIPMENT REQUIRED)
Insulin, derived froM porcine pancreas
Insulin porcine for system suitability
Insulin porcine for system suitability CRS
8a-l-threonine-10a-l-isoleucine-insulin(ox
Insulin (ox), 8A-l-threonine-10A-l-isoleucine-
Insulin (Pork) (100 mg) (COLD SHIPMENT REQUIRED)
Insulin from porcine pancreas, ≥27 USP units/mg(HPLC) | [EINECS(EC#)]
235-703-3 | [Molecular Formula]
C256H381N65O76S6 | [MDL Number]
MFCD03457237 | [Molecular Weight]
5777.54 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder | [storage temp. ]
−20°C
| [solubility ]
It can be solubilized in dilute acetic or hydrochloric acid, pH 2-3. | [form ]
powder
| [color ]
White to Off-White | [biological source]
Porcine pancreas | [Merck ]
13,5003 | [Specific Activity]
≥27USP units/mg | [Sequence]
Chain 1:Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala Chain 2:Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn (Disulfide bridge:1'Cys7-2'Cys7,1'Cys19-2'Cys20,1'Cys6-2'Cys11) | [Stability:]
Hygroscopic | [Uses]
Hormone; treatment of diabetes mellitus. |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white powder | [Description]
Porcine Insulin is a double-chain protein with a molecular mass of 5778, containing 51 amino acids (A-21 and B-30 chains) connected by a disulfide bond. Porcine Insulin has a high degree of similarity to human insulin, differing only in the 30th amino acid. porcine Insulin regulates the uptake, utilisation and storage of glucose, amino acids and fatty acids in cells and inhibits the breakdown of glycogen, proteins and lipids. Therefore, it is used to control hyperglycaemia in diabetic patients. | [Biological Functions]
Insulin has anabolic properties that include the stimulation of both skeletal muscle and liver cells to incorporate glucose and convert it to glycogen, to synthesize proteins from amino acids in the blood, and to act on fat cells to enhance their uptake of glucose and the synthesis of fat. In short, insulin encourages anabolism rather than catabolism, because it promotes the synthesis of glycogen, proteins, and lipids. A deficiency of insulin, which characterizes the disease diabetes mellitus (DM), causes extreme changes in the entire metabolic pattern of individuals with DM. Patients with DM often demonstrate elevated blood glucose levels, excess glucose in the urine, and failure to properly utilize carbohydrate and lipids. | [Biochem/physiol Actions]
Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. |
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