Identification | Back Directory | [Name]
3-Hydroxy-N,N-dimethyl-4-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-2-pyridinecarboxamide | [CAS]
1255915-27-5 | [Synonyms]
3-Hydroxy-N,N-dimethyl-4-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-2-pyridinecarboxamide | [Molecular Formula]
C22H26N4O5 | [MOL File]
1255915-27-5.mol | [Molecular Weight]
426.47 |
Hazard Information | Back Directory | [Uses]
SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intracellular pocket occupied by SQA1 overlaps with the G protein binding site and stabilizes the closed conformation of the intracellular pocket[1]. | [References]
[1] David Jonathan Wasilko, et al. Structural basis for CCR6 modulation by allosteric antagonists. bioRxiv. April 06, 2024 |
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