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ChemicalBook--->CAS DataBase List--->1254733-98-6

1254733-98-6

1254733-98-6 Structure

1254733-98-6 Structure
IdentificationBack Directory
[Name]

SSTR5 antagonist 2 TFA
[CAS]

1254733-98-6
[Synonyms]

SSTR5 antagonist 2 TFA
[Molecular Formula]

C34H36F4N2O7
[MDL Number]

MFCD32062762
[MOL File]

1254733-98-6.mol
[Molecular Weight]

660.66
Hazard InformationBack Directory
[Uses]

SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM)[1].
[in vivo]

SSTR5 antagonist 2 (10 mg/kg, orally) increases both total and active circulating incretin hormone GLP1 levels in mice at a dose of 10 mg/kg[1].
SSTR5 antagonist 2 increases pancreatic insulin secretion as well as total and active GLP1 release, and demonstrates synergistic effects in combination with DPP4 inhibitors[1].

Animal Model:Rodent diabetic model without risk of hypoglycemia[1].
Dosage:10 mg/kg.
Administration:Orally.
Result:Increased both total and active circulating incretin hormone GLP1 levels.
[References]

[1] Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. DOI:10.1021/acsmedchemlett.8b00305
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