| Identification | Back Directory | [Name]
3Β-HYDROXY-7-OXO-5-CHOLESTENOIC ACID | [CAS]
1246298-64-5 | [Synonyms]
3Β-HYDROXY-7-OXO-5-CHOLESTENOIC ACID
3ss-hydroxy-7-oxo-5-cholestenoic acid
3β-hydroxy -7-oxo-5-cholestenoic acid
Cholest-5-en-26-oic acid, 3-hydroxy-7-oxo-, (3β,25R)- | [Molecular Formula]
C27H42O4 | [MDL Number]
MFCD19704918 | [MOL File]
1246298-64-5.mol | [Molecular Weight]
430.63 |
| Chemical Properties | Back Directory | [Boiling point ]
590.5±33.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
powder | [pka]
4.81±0.21(Predicted) |
| Hazard Information | Back Directory | [Uses]
3?-Hydroxy-7-oxo-5-cholestenoic acid is used in the study of mammalian pathological biochemistry for defective cholesterol metabolism in amyotrophic lateral schlerosis. | [Biological Activity]
3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) acts as a ligand for liver X receptors (LXR) and activates them at micromolar concentration. 3βH,7O-CA favors the islet-1+ cells synthesis and islet-1–GFP expression. 3βH,7O-CA also mediates oculomotor neurons maturation and its conversion to 3β,7β-dihydroxycholest-5-en-(25S)26-oic acid (3β,7β-diHCA) is catalyzed by the enzyme hydroxysteroid 11-β dehydrogenase. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
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