| Identification | Back Directory | [Name]
PROTAC Linker 27 | [CAS]
1246286-33-8 | [Synonyms]
Tos-PEG2-NH2
PROTAC Linker 27
2-(2-aminoethoxy)ethyl 4-methylbenzenesulfonate | [Molecular Formula]
C11H17NO4S | [MDL Number]
MFCD32263212 | [MOL File]
1246286-33-8.mol | [Molecular Weight]
259.32 |
| Hazard Information | Back Directory | [Biological Activity]
Tos-PEG2-NH2 (PROTAC Linker 27) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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