| Identification | Back Directory | [Name]
4,6-Diamino-2-(-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine | [CAS]
124137-35-5 | [Synonyms]
4,6-Diamino-2-(-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
4,6-Diamino-2-(beta-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-2,5-dihydro-2-(beta-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one | [Molecular Formula]
C10H14N6O4 | [MOL File]
124137-35-5.mol | [Molecular Weight]
282.256 |
| Chemical Properties | Back Directory | [Melting point ]
230 °C (decomp)(Solv: water (7732-18-5)) | [Boiling point ]
805.6±75.0 °C(Predicted) | [density ]
2.25±0.1 g/cm3(Predicted) | [pka]
12.93±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
2-β-D-Ribofuranosyl-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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