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ChemicalBook--->CAS DataBase List--->123955-10-2

123955-10-2

123955-10-2 Structure

123955-10-2 Structure
IdentificationBack Directory
[Name]

Almokalant
[CAS]

123955-10-2
[Synonyms]

H 234?/09
Almokalant
Benzonitrile, 4-[3-[ethyl[3-(propylsulfinyl)propyl]amino]-2-hydroxypropoxy]-
[Molecular Formula]

C18H28N2O3S
[MDL Number]

MFCD00864746
[MOL File]

123955-10-2.mol
[Molecular Weight]

352.49
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Uses]

Almokalant is a class III antiarrhythmic agent, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
[in vivo]

Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats[1].

[storage]

Store at -20°C
[References]

[1] Wellfelt K, et al. Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species. Reprod Toxicol. 1999 Mar-Apr;13(2):93-101. DOI:10.1016/s0890-6238(98)00066-5
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