| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one,2-[5-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxyphenyl]-2,3-dihydro-5,7-dihydroxy-,(2S)- | [CAS]
123702-95-4 | [Synonyms]
Kuwanon U
4H-1-Benzopyran-4-one,2-[5-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxyphenyl]-2,3-dihydro-5,7-dihydroxy-,(2S)- | [Molecular Formula]
C26H30O6 | [MOL File]
123702-95-4.mol | [Molecular Weight]
438.513 |
| Hazard Information | Back Directory | [Uses]
Kuwanon U is a potent cholinesterase inhibitor with IC50s of 19.69, 10.11 μM and Kis of 6.48, 9.59 μM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD)[1]. | [IC 50]
AChE: 19.69 μM (IC50); AChE: 6.48 μM (IC50); BChE: 10.11 μM (Ki); BChE: 9.59 μM (Ki) | [References]
[1] Kim JY, et al. Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. J Agric Food Chem. 2011 May 11;59(9):4589-96. DOI:10.1021/jf200423g |
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