| Identification | Back Directory | [Name]
LY-2608204 | [CAS]
1234703-40-2 | [Synonyms]
CS-898
LY-2608204
LY-2608024
LY-2608204; LY 2608204
(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]cyclopropanecarboxamide
(1R,2S)-2-cyclohexyl-1-(4-(cyclopropylsulfonyl)phenyl)-N-(5-((2-(pyrrolidin-1-yl)ethyl)thio)thiazol-2-yl)cyclopropanecarboxaMide
Cyclopropanecarboxamide, 2-cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]-, (1R,2S)-
(1R,2S)-2-Cyclohexyl-1-[4-(cyclopropylsulfonyl)phenyl]-N-[5-[[2-(1-pyrrolidinyl)ethyl]thio]-2-thiazolyl]cyclopropanecarboxamide LY 2608204 | [Molecular Formula]
C28H37N3O3S3 | [MDL Number]
MFCD21609257 | [MOL File]
1234703-40-2.mol | [Molecular Weight]
559.81 |
| Chemical Properties | Back Directory | [density ]
1.35 | [storage temp. ]
Store at -20°C | [solubility ]
≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH | [form ]
solid | [pka]
8.17±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
LY2608204 is an activator of glucokinase (GK; EC50 = 42 nM). It stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC50 = 579 nM). LY2608204 (30 mg/kg) decreases plasma glucose levels in a dose-dependent manner in fasted rats. | [Uses]
Globalagliatin (LY2608204) is an orally active glucokinase (GK) activator with an EC50 of 42 nM. Globalagliatin also stimulates glucose metabolism in rat insulinoma INS1-E cells with an EC50 of 579 nM. Globalagliatin targets both pancreatic β-cells and hepatocytes. Globalagliatin is promising for research of type 2 diabetes[1][2][3]. | [target]
GK | [storage]
Store at -20°C | [References]
[1] kj filipski, bd stevens . glucokinase activators in development .2012 books |
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