| Identification | Back Directory | [Name]
6H-Pyrazolo[3,4-b]pyridin-6-one, 1-(3-chloro-4-methylphenyl)-1,4,5,7-tetrahydro-3-methyl-4-[(5-methyl-2-thienyl)carbonyl]- | [CAS]
1223771-84-3 | [Synonyms]
6H-Pyrazolo[3,4-b]pyridin-6-one, 1-(3-chloro-4-methylphenyl)-1,4,5,7-tetrahydro-3-methyl-4-[(5-methyl-2-thienyl)carbonyl]- | [Molecular Formula]
C20H18ClN3O2S | [MOL File]
1223771-84-3.mol | [Molecular Weight]
399.89 |
| Hazard Information | Back Directory | [Uses]
S9-A13 is a potent and selective inhibitor SLC26A9, with the IC50 of 90.9 nM, without inhibiting other members of the SLC26 family such as SLC26A3, SLC26A4, and SLC26A6. S9-A13 can inhibits SLC26A9 Cl- currents in cells that lack expression of CFTR[1]. | [References]
[1] Sungwoo Jo, et al. The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion. FASEB J. 2022 Nov;36(11):e22534. DOI:10.1096/fj.202200313RR |
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