| Identification | Back Directory | [Name]
9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- | [CAS]
1199523-24-4 | [Synonyms]
ML920
ML092
Cruzain-IN-1
092 Cruzain-IN-1
ML092 Cruzain-IN-1
Cruzain-IN-1(ML092)
Cruzain inhibitor 1
6-(3,5-difluoroanilino)-9-ethylpurine-2-carbonitrile
9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- | [Molecular Formula]
C14H10F2N6 | [MDL Number]
MFCD18206889 | [MOL File]
1199523-24-4.mol | [Molecular Weight]
300.27 |
| Chemical Properties | Back Directory | [Boiling point ]
504.1±60.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO : 80 mg/mL (266.43 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
-1.62±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM. | [Definition]
ChEBI: 6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile is a member of 6-aminopurines. | [IC 50]
Trypanosoma: 10 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Lee GM, et al. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18;51(50):10087-98. DOI:10.1021/bi301305k |
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