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ChemicalBook--->CAS DataBase List--->1188277-05-5

1188277-05-5

1188277-05-5 Structure

1188277-05-5 Structure
IdentificationBack Directory
[Name]

Flanvotumab
[CAS]

1188277-05-5
[Synonyms]

Flanvotumab
Flanvotumab (anti-TYRP1)
Research Grade Flanvotumab (DHD25201)
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Uses]

Flanvotumab (IMC-20D7S) is a human monoclonal antibody targeting to tyrosinase-related protein (TYRP1), specifically expressed in melanocytes and melanoma cells. Flanvotumab acts function via natural killing-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Flanvotumab has potent anti-tumor activity and good tolerance[1].
[References]

[1] Khalil DN, et al. An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma. Clin Cancer Res. 2016 Nov 1;22(21):5204-5210. DOI:10.1158/1078-0432.CCR-16-1241
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