| Identification | Back Directory | [Name]
Cefquinome sulfate | [CAS]
118443-89-3 | [Synonyms]
1-(((6R,7R)
HR 111V Sulfate
[6R-[6α,7β(Z)]]-1-
CEFQUINOME SULFATE
Cefoquiuonie sulphate
CefquinoMe Sulfate DMF
Cefquinome sulfate USP/EP/BP
-5,6,7,8-tetrahydroquinolin-1-ium hydrogensulfate
-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)
7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Quinolinium, 1-(6R,7R)-7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-2-carboxy-8-oxo-5-thia-1-azabicyclo4.2.0oct-2-en-3-ylmethyl-5,6,7,8-tetrahydro-, sulfate (1:1)
1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-5,6,7,8-tetrahydro-quinoliniuM Sulfate
1-(((6R,7R)-7-((Z)-2-(2-AMinothiazol-4-yl)-2-(MethoxyiMino)acetaMido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)Methyl)-5,6,7,8-tetrahydroquinolin-1-iuM hydrogensulfate
(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate sulfate | [EINECS(EC#)]
800-041-1 | [Molecular Formula]
C23H26N6O9S3 | [MDL Number]
MFCD23381671 | [MOL File]
118443-89-3.mol | [Molecular Weight]
626.682 |
| Questions And Answer | Back Directory | [Definition]
NCIt: Cefquinome Sulfate is the sulfate form of cefquinome, a semisynthetic, broad-spectrum, fourth-generation aminothiazolyl cephalosporin with antibacterial activity. Cefquinome binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
| Chemical Properties | Back Directory | [Melting point ]
161-166°C | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChIKey]
KYOHRXSGUROPGY-NIZYHBPXNA-N | [SMILES]
S(O)([O-])(=O)=O.C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3=CSC(N)=N3)=N\OC)C(=O)N12)C[N+]1=CC=CC2CCCCC1=2)(=O)O |&1:10,12,r| |
| Hazard Information | Back Directory | [Description]
Cefquinome sulfate(118443-89-3) is a veterinary, parenteral, fourth-generation cephalosporin belonging to the class of aminothiazolyl compounds. They have high cell permeability and high stability to beta-lactamases. They have broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria (e.g. Pseudomonas aeruginosa and Enterobacteriaceae).
| [Chemical Properties]
Cefquinome sulfate is Off-White Solid
| [Uses]
Cefquinome sulfate(118443-89-3) is an antibacterial used in veterinary medicine. Used in the treatment of infections caused by pathogens such as S. aureus, E. coli, Streptococcus, P. multocida and A. pleuropneumoniae. Also used to trea t mastitis in dairy cows.
| [Mechanism of action]
Cefquinome sulfate(118443-89-3) acts by inhibition of the cell wall synthesis, but it has a relatively short half-life of about 2.5 hours. It is less than 5% protein bound and is excreted unchanged in the urine.
| [IC 50]
β-lactam | [storage]
4°C, protect from light |
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