午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook--->CAS DataBase List--->1173657-73-2

1173657-73-2

1173657-73-2 Structure

1173657-73-2 Structure
IdentificationBack Directory
[Name]

IM-93
[CAS]

1173657-73-2
[Synonyms]

IM-93
[Molecular Formula]

C21H28N4O2
[MOL File]

1173657-73-2.mol
[Molecular Weight]

368.47
Chemical PropertiesBack Directory
[Boiling point ]

540.2±50.0 °C(Predicted)
[density ]

1.17±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL; Ethanol: 1mg/mL
[form ]

A crystalline solid
[pka]

9.48±0.28(Predicted)
[color ]

Yellow to orange
Hazard InformationBack Directory
[Description]

IM-93 is a dual inhibitor of ferroptosis and NETosis.1 It inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC50s =1.8 and 1.9 nM, respectively), as well as decreases NETosis and lipid peroxidation induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human peripheral blood neutrophils when used at concentrations ranging from 1.6 to 25 μM. IM-93 also inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC50 = 0.45 μM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells when used at a concentration of 25 μM.
[Uses]

IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 μM for cell death inhibition[1].
[storage]

Store at -20°C
[References]

1. Dodo, K., Kuboki, E., Shimizu, T., et al. Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis ACS Med. Chem. Lett. 10(9),1272-1278(2019).
1173657-73-2 suppliers list
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
Website: www.glpbio.cn
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: Nanjing Tengyi Biotechnology Co., Ltd  
Tel: 025-58851786 17714337195
Website: https://tybiochem.com/
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name:   
Tel: 4008-099-669
Website: http://www.yuhua99.com/ShowSupplierProductsList112975/0.htm
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Website: www.caymanchem.com
Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
Tel: 51288865780
Website: www.biosynth.com
Company Name: Neobioscience Co., Ltd.  
Tel: 4006-800-892
Website: www.nbs-bio.com
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Website: www.caymanchem.com
Tags:1173657-73-2 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.