Identification | Back Directory | [Name]
4-Methyl-3-(hydroxyMethyl)Morpholine | [CAS]
1159598-86-3 | [Synonyms]
4-Methyl-3-morpholinemethanol 3-Morpholinemethanol, 4-methyl- (4-Methylmorpholin-3-yl)methanol 4-Methyl-3-(hydroxyMethyl)Morpholine | [Molecular Formula]
C6H13NO2 | [MDL Number]
MFCD26792530 | [MOL File]
1159598-86-3.mol | [Molecular Weight]
131.17 |
Chemical Properties | Back Directory | [Boiling point ]
201.1±15.0 °C(Predicted) | [density ]
1.031±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
14.85±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid |
Hazard Information | Back Directory | [Synthesis]
Step 2: Preparation of (4-methylmorpholin-3-yl)methanol
To a solution of morpholin-3-ylmethanol (0.540 g, 4.6 mmol) in methanol (20 mL) was added formaldehyde (1.86 g, 23 mmol, 37% aqueous solution) and palladium/carbon catalyst (0.200 g). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (1.0 atm). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio: methanol:dichloromethane=1:15) to afford (4-methylmorpholin-3-yl)methanol (0.130 g, 22% yield) as a yellow oil. | [References]
[1] Patent: US2016/168090, 2016, A1. Location in patent: Paragraph 0927-0928 |
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Energy Chemical
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