| Identification | Back Directory | [Name]
CPNQ | [CAS]
115687-05-3 | [Synonyms]
B2
CPNQ
SIRT2 Inhibitor, B2
Linazolamide intermediate B impurity 2
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone
Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]- | [Molecular Formula]
C20H17ClN4O3 | [MDL Number]
MFCD02039810 | [MOL File]
115687-05-3.mol | [Molecular Weight]
396.83 |
| Chemical Properties | Back Directory | [Melting point ]
174-176°C | [Boiling point ]
645.5±55.0 °C(Predicted) | [density ]
1.412±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
H2O: insoluble <2mg/mL | [form ]
solid | [pka]
2.30±0.29(Predicted) | [color ]
brown | [Water Solubility ]
H2O: insoluble <2mg/mL
DMSO: >5mg/mL |
| Hazard Information | Back Directory | [Uses]
B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer. | [Definition]
ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine. | [Biological Activity]
Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity. |
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