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ChemicalBook--->CAS DataBase List--->1139875-74-3

1139875-74-3

1139875-74-3 Structure

1139875-74-3 Structure
IdentificationBack Directory
[Name]

GSK-3β Inhibitor XVIII
[CAS]

1139875-74-3
[Synonyms]

GSK3β-IN-1a
GSK3β Inhibitor XVIII
GSK-3β Inhibitor XVIII
GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
[Molecular Formula]

C20H20ClN5OS
[MDL Number]

MFCD32671859
[MOL File]

1139875-74-3.mol
[Molecular Weight]

413.92
Chemical PropertiesBack Directory
[Boiling point ]

632.3±65.0 °C(Predicted)
[density ]

1.358±0.06 g/cm3(Predicted)
[storage temp. ]

+2C to +8C
[solubility ]

DMSO: soluble
[form ]

White solid
[pka]

6?+-.0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.
[Uses]

GSK-3β inhibitor 8, a thiophenacil derivative, is an effective and selective inhibitor of GSK-3β (IC50=64 nM). GSK-3β inhibitor 8 negatively regulated Wnt signaling pathway and stimulated β cell proliferation[1][2].
[IC 50]

GSK-3β: 64 nM (IC50)
[References]

[1] Wang W, et al. Identification of small-molecule inducers of pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32. DOI:10.1073/pnas.0811848106
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