| Identification | Back Directory | [Name]
3-Pyridinesulfonamide, 5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]- | [CAS]
1092565-44-0 | [Synonyms]
MMV024101
MMV-024101
MMV 024101
TCMDC134293
TCMDC-134293
TCMDC 134293
3-Pyridinesulfonamide, 5-[8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl]- | [Molecular Formula]
C16H12N6O2S | [MOL File]
1092565-44-0.mol | [Molecular Weight]
352.37 |
| Hazard Information | Back Directory | [Description]
MMV024101 is a PI4K inhibitor. MMV024101 showed submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent compound remaining after 30 min of incubation. | [Uses]
MMV024101 shows potency against P. falciparum NF54 with an IC50 value of 543 nM, which has antiplasmodial activity[1]. | [References]
[1] Kandepedu N, et al. Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria. J Med Chem. 2018 Jul 12;61(13):5692-5703. DOI:10.1021/acs.jmedchem.8b00648 |
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