| Identification | Back Directory | [Name]
3-(4-((7-hydroxy-6-methyl-2,3-dihydro-1H-inden-4-yl)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)propanoic acid | [CAS]
1092551-88-6 | [Synonyms]
Omzotirome
TRC-150094
Omzotirome (TRC150094)
Phenylbutazone Impurity 39
3-(4-((7-hydroxy-6-Methyl-2,3-dihydro-1H-inden-4-yl)Methyl)-3,5-
3-[4-(7-hydroxy-6-methyl-indan-4-ylmethyl)-3,5-dimethyl-pyrazol-1-yl]-propionic acid
4-[(2,3-dihydro-7-hydroxy-6-methyl-1H-inden-4-yl)methyl]-3,5-dimethyl-1H-Pyrazole-1-propanoic acid
1H-Pyrazole-1-propanoic acid, 4-[(2,3-dihydro-7-hydroxy-6-methyl-1H-inden-4-yl)methyl]-3,5-dimethyl-
3-(4-((7-hydroxy-6-methyl-2,3-dihydro-1H-inden-4-yl)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)propanoic acid | [Molecular Formula]
C19H24N2O3 | [MDL Number]
MFCD19053219 | [MOL File]
1092551-88-6.mol | [Molecular Weight]
328.41 |
| Hazard Information | Back Directory | [Uses]
Omzotirome (TRC150094), a functional analog of iodothyronines, can be used for the research of hyperlipidaemia (WO2008149379)[1][2]. | [in vivo]
Omzotirome (0.750 mg/ 100 g; i.p.) with high-fat diet rats have significantly less visceral adipose tissue (vs. HFD rats) and exhibit altered metabolism in two major tissues that are very active metabolically and exhibit increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats[1].
Omzotirome, a functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet (HFD)[1]. | Animal Model: | Male Wistar rats (8 weeks)[1] | | Dosage: | 0.750 mg/ 100 g | | Administration: | I.p. | | Result: | With high-fat diet rats had significantly less visceral adipose tissue (vs. HFD rats) and exhibited altered metabolism in two major tissues that were very active metabolically and exhibited increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats.
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| [References]
[1] WO2008149379
[2] Cioffi F, et al. TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet. FASEB J. 2010;24(9):3451-3461. DOI:10.1096/fj.10-157115 |
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