| Identification | Back Directory | [Name]
ELASTASE SUBSTRATE IV, COLORIMETRIC | [CAS]
108392-27-4 | [Synonyms]
Suc-AAP-Abu-pNA
ELASTASE SUBSTRATE IV
SUC-ALA-ALA-PRO-ABU-PNA
Elastase Colorimetric Substrate IV
ELASTASE SUBSTRATE IV, COLORIMETRIC
SUC-AAP-ABU-PNA;ELASTASE COLORIMETRIC SUBSTRATE IV
SUC-ALA-ALA-PRO-ABU-PNA ; ELASTASE SUBSTRATE IV, COLORIMETRIC
Butanamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-2-amino- (9CI) | [Molecular Formula]
C25H34N6O9 | [MDL Number]
MFCD31664887 | [MOL File]
108392-27-4.mol | [Molecular Weight]
562.57 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
ethanol: 1mg/mL
water: soluble | [form ]
lyophilized solid | [color ]
white to off-white | [Water Solubility ]
Water: 1 mg/ml | [Sequence]
{Suc}-Ala-Ala-Pro-{Abu}-{pNA} |
| Hazard Information | Back Directory | [Uses]
Suc-AAP-Abu-pNA (Colorimetric Elastase Substrate) is a specific substrate for pancreatic elastase (Km = 100 μM; Kcat/Km = 35,300 s-1 M-1 for rat pancreatic elastase; Km = 30 μM; Kcat/Km = 351,000 s-1 M-1 for porcine pancreatic elastase). Suc-AAP-Abu-pNA also promotes OPC migration[1]. | [Biological Activity]
Cell permeable: no''Primary Target
A specific substrate for pancreatic elastase''Product does not compete with ATP.''Reversible: no''km = 100 μM; kcat/ Km = 35,000 M-1 s-1 for r at pancreatic elastase; Km = 30 μM; kcat/Km = 35,000 M-1 s-1 for porcine | [References]
[1] Largman C. Isolation and characterization of rat pancreatic elastase. Biochemistry. 1983 Aug 2;22(16):3763-70. DOI:10.1021/bi00285a008 |
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