| Identification | Back Directory | [Name]
MF592 | [CAS]
1064195-48-7 | [Synonyms]
MF592
Benzenesulfonamide, 2,6-dichloro-N-[[[1-[[4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]amino]carbonyl]- | [Molecular Formula]
C34H33Cl2N3O6S | [MOL File]
1064195-48-7.mol | [Molecular Weight]
682.61 |
| Hazard Information | Back Directory | [Description]
MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further development. | [Uses]
MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs. | [References]
[1] Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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