| Identification | Back Directory | [Name]
VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS | [CAS]
106021-96-9 | [Synonyms]
Sclavo peptide
IL-1B (163-171) (HUMAN)
interleukin-1beta(163-171
IL-1BETA (163-171) (HUMAN)
INTERLEUKIN-1B (163-171) (HUMAN)
Interleukin-1β (163-171) (human)
β-Interleukin I (163-171), human
b-Interleukin I (163-171), human
β-Interleukin I (163-171), human
BETA-INTERLEUKIN I (163-171), HUMAN
VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS
INTERLEUKIN-1BETA (163-171) (HUMAN)
interleukin-1B fragment 163-171 human
interleukin-1β fragment 163-171 human
Interleukin-1β Fragment 163-171 human
H-VAL-GLN-GLY-GLU-GLU-SER-ASN-ASP-LYS-OH
INTERLEUKIN-1BETA FRAGMENT 163-171 HUMAN
IL-1β (163-171) (human)|β-Interleukin I (163-171),human
IL-1β (163-171) (human)|β-Interleukin I (163-171),human
L-Lysine, L-valyl-L-glutaminylglycyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-asparaginyl-L-α-aspartyl- | [Molecular Formula]
C39H64N12O19 | [MDL Number]
MFCD00076554 | [MOL File]
106021-96-9.mol | [Molecular Weight]
1004.99 |
| Chemical Properties | Back Directory | [Boiling point ]
1682.6±65.0 °C(Predicted) | [density ]
1.419±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
insoluble in EtOH; ≥100.4 mg/mL in DMSO; ≥24.75 mg/mL in H2O | [form ]
solid | [pka]
3.14±0.10(Predicted) | [color ]
white | [biological source]
synthetic | [Water Solubility ]
water: soluble 1mg/mL, clear, colorless |
| Hazard Information | Back Directory | [Uses]
β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations[1][3][4]. | [Biological Activity]
β-interleukin i (163-171), human(c39h64n12o19), a peptide with the sequence val-gln-gly-glu-glu-ser-asn-asp-lys, mw= 1005. interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). interleukin 1 alpha and interleukin 1 beta (il-1 alpha and il-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.interleukin-1 beta (il-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the il1b gene. il-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). cytosolic thiol protease cleaves the product to form mature il-1β. il-1β is a member of the interleukin 1 cytokine family. this cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.figure1 formula of b-interleukin i (163-171), humanfigure2 structure of b-interleukin i | [Biochem/physiol Actions]
IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form. | [in vivo]
β-Interleukin I (163-171), human (50 μg, daily, a poorly immunogenic fibrosarcoma (CE-2) of BALB/c mice model) induces a consistent but limited inhibition of tumor growth[2].
β-Interleukin I (163-171), human (1 μmole/kg, i.v.) together with the T-dependent antigen SRBC increases the primary immune response against the antigen[3].
| [storage]
Store at -20°C | [References]
1. Contassot E, Beer HD, French LE (2012). "Interleukin-1, inflammasomes, autoinflammation and the skin". Swiss Med Wkly 142: w135902. Matzinger P (2012). "The evolution of the danget theory. Interview by Lauren Constable, Commissioning Editor". Expert Rev Clin Immunol 8 (4): 311-7.3. Sahoo M, Ceballos-Olvera I, del Barrio L, Re F (2011). "Role of the inflammasome, IL-1β, and IL-18 inbacterial infections". ScientificWorldJournal 11: 2037-50. |
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