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ChemicalBook--->CAS DataBase List--->105925-39-1

105925-39-1

    105925-39-1 Structure

    105925-39-1 Structure
    IdentificationBack Directory
    [Name]

    Tubulin inhibitor 6
    [CAS]

    105925-39-1
    [Synonyms]

    iHAP1
    Tubulin inhibitor 6
    Methanone, (2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)-
    [Molecular Formula]

    C20H14ClNO2S
    [MOL File]

    105925-39-1.mol
    [Molecular Weight]

    367.85
    Chemical PropertiesBack Directory
    [Melting point ]

    155-157 °C
    [Boiling point ]

    549.1±50.0 °C(Predicted)
    [density ]

    1.364±0.06 g/cm3(Predicted)
    [storage temp. ]

    Store at -20°C
    [solubility ]

    DMSO: 62.5 mg/mL (169.91 mM)
    [form ]

    A crystalline solid
    [pka]

    -5.56±0.20(Predicted)
    [color ]

    White to off-white
    Safety DataBack Directory
    [Symbol(GHS) ]


    GHS07
    [Signal word ]

    Warning
    [Hazard statements ]

    H302-H319-H335-H315
    [Precautionary statements ]

    P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501
    Hazard InformationBack Directory
    [Uses]

    Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].
    [Biological Activity]

    Tubulin inhibitor 6 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and efficiently kills malignant cells.
    [in vitro]

    Tubulin inhibitor 6 displays submicromolar antiproliferative activity.

    [target]

    TargetValue
    PP2A
    ()
    [storage]

    Store at -20°C
    [References]

    [1] Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. DOI:10.1021/jm200436t
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