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ChemicalBook--->CAS DataBase List--->104777-68-6

104777-68-6

104777-68-6 Structure

104777-68-6 Structure
IdentificationBack Directory
[Name]

plantamajoside
[CAS]

104777-68-6
[Synonyms]

Y0160
C10485
dihoside A
Plantamoside
plantamajoside
Purpureaside A
Plantamajoside, 98%, from Plantago major L.
(E)-6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-((3,4,5-trihydroxy-6-(hydroxymet
2-(3,4-Dihydroxyphenyl)ethyl 4-O-(3,4-dihydroxycinnamoyl)-3-O-(β-D-glucopyranosyl)-β-D-glucopyranoside
b-D-Glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl 3-O-b-D-glucopyranosyl-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-β-D-glucopyranosyl-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
2-(3,4-Dihydroxyphenyl)ethyl 3-O-beta-D-glucopyranosyl-beta-D-glucopyranoside 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
(2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate
[Molecular Formula]

C29H36O16
[MDL Number]

MFCD20527298
[MOL File]

104777-68-6.mol
[Molecular Weight]

640.59
Chemical PropertiesBack Directory
[Boiling point ]

953.0±65.0 °C(Predicted)
[density ]

1.66
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

Soluble in methanol and water
[form ]

powder
[pka]

9.31±0.10(Predicted)
[color ]

White
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Safety Statements ]

24/25
[HS Code ]

29389090
Hazard InformationBack Directory
[Uses]

food and beverages
[Definition]

ChEBI: Plantamajoside is a hydroxycinnamic acid.
[in vivo]

Plantamajoside (20-80 mg/kg) promotes the recovery of neurological function and protects the tissue structure of the spinal cord after ASCI in a rat model of acute spinal cord injury[15].
Plantamajoside (25-100 mg/kg, i.p., 24 h) alleviates acute sepsis-induced organ dysfunction through inhibiting the TRAF6/NF-κB axis in mice[16].
Plantamajoside (10-40 mg/kg, p.o., 4 weeks) has protective activities against Cd-induced renal injury in rats[17].
Plantamajoside (25-100 mg/kg, i.p., three times at 6, 12, 18 h) ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-κB and MAPK activation in mice[18].
Plantamajoside (20-80 mg/kg, i.p., once a day for 4 weeks) modulates immune dysregulation and hepatic lipid metabolism in rats with nonalcoholic fatty liver disease via AMPK/Nrf2 elevation[19].

Animal Model:Acute sepsis C57BL/6 male mice model by caecal ligation and perforation (CLP)[16]
Dosage:25, 50, 100 mg/kg
Administration:Intraperitoneal injection (i.p.), 24 h
Result:Extended survival in CLP model.
Improved acute sepsis-triggered organ damage.
Alleviated acute sepsis-triggered apoptosis.
Relieved acute sepsis-triggered inflammatory response.
Improved acute sepsis-triggered organ damage via mediating the TRAF6/NF-κB pathway.
Improved acute sepsis-triggered apoptosis and inflammation via regulating the TRAF6/NF-κB pathway.
Spectrum DetailBack Directory
[Spectrum Detail]

plantamajoside(104777-68-6)MS
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