| Identification | Back Directory | [Name]
3'-Azido-N6-benzoyl-3'-deoxyadenosine | [CAS]
103597-10-0 | [Synonyms]
3'-azido-3-deoxy-N6-benzoyladenosine
3'-azido-N-benzoyl-3'-deoxy-adenosine
3'-Azido-N6-benzoyl-3'-deoxyadenosine
N-[9-((2R,3R,4S,5S)-4-Azido-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl]-benzamide | [Molecular Formula]
C17H16N8O4 | [MDL Number]
MFCD31537255 | [MOL File]
103597-10-0.mol | [Molecular Weight]
396.36 |
| Hazard Information | Back Directory | [Uses]
3’-Azido-N6-benzoyl-3’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-N6-benzoyl-3’-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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