| Identification | Back Directory | [Name]
2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide | [CAS]
1030203-81-6 | [Synonyms]
HS38
HS-38
(HS38)
HS38 >=95% (HPLC)
NASYEGAVCTZSDO-UHFFFAOYSA-N
2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide
2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide
Propanamide, 2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]- | [Molecular Formula]
C14H12ClN5O2S | [MDL Number]
MFCD10610687 | [MOL File]
1030203-81-6.mol | [Molecular Weight]
349.8 |
| Chemical Properties | Back Directory | [Boiling point ]
615.0±65.0 °C(Predicted) | [density ]
1.65±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
14.95±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
HS 38 is a specific serine/threonine protein kinase inhibitor that affects the regulation of programmed cell-death and phosphorylation of smooth-muscle myelin. | [Biological Activity]
HS38 is a potent and selective ATP-competitive inhibitor of Death-associated protein kinases DAPK1 (IC50 = 200 nM89% inhibition at 10 RM) and ZIPK (Zipper-interacting protein kinasealso called DAPK3) th at regulate programmed cell deathand also inhibits the closely related PIM3 kinase (IC50 = 200 nM76% inhibition at 10 RM). In addition to mediating apoptosisDAPK1 and ZIPK regulate both non-muscle and smooth muscle myosin phosphorylation. HS38 specifically targeted ZIPK in smooth muscleand decreased contractile force generated in mouse aortarabbit ileumand calyculin A stimulated arterial muscle. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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