| Identification | Back Directory | [Name]
[D-P-CL-PHE(6),LEU(17)]-VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT | [CAS]
102805-45-8 | [Synonyms]
Cpl-vip
[(4CL)DPHE6,LEU17] VIP
[d-p-cl-phe6, leu17]-vip
Vip, 4-cl-Phe(6)-Leu(17)-
(p-Chloro-D-Phe?,Leu1?)-VIP
6-(4-Chlorophenylalanyl)-17-leucine-vip
[PCL-D-PHE6, LEU17]VIP, HUMAN, PORCINE, RAT
(p-Chloro-D-Phe6,Leu17)-VIP (huMan, Mouse, rat)
[(4CL)DPHE6,LEU17] VASOACTIVE INTESTINAL PEPTIDE
[P-CHLORO-D-PHE6,LEU17]-VIP, HUMAN, PORCINE, RAT
[D-P-CL-PHE6,LEU17]-VASOACTIVE INTESTINAL PEPTIDE
4-chloro-phe(6)-leu(17)-vasoactiveintestinalpeptid
(D-P-CL-PHE6,LEU17)-VASOACTIVE*INTESTINA L PEPTIDE H
(D-PHE(4-CL)6,LEU17)-VIP (HUMAN,BOVINE, PORCINE, RAT)
6-(4-Chloro-Phe)-17-Leu-vasoactive intestinal peptide
vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-
[D-P-CL-PHE6,LEU17]-VASOACTIVE INTESTINAL PEPTIDE HUMAN
(P-CHLORO-D-PHE6,LEU17)-VIP (HUMAN, BOVINE, PORCINE, RAT)
[d-p-cl-phe6,leu17]-vasoactiveintestinalpeptidefromprocine
Vasoactive intestinal peptide, 4-chlorophenylalanyl(6)-leucine(17)-
[D-P-CL-PHE(6),LEU(17)]-VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT
(p-Chloro-D-Phe6,Leu17)-VIP (human, bovine, porcine, rat)|[4ClDPhe6,Leu17] VIP
D-p-Cl-Phe6, Leu17]-Vasoactive Intestinal Peptide human, porcine, rat >=97% (HPLC)
[P-CHLORO-D-PHE6, LEU17]-VASOACTIVE INTESTINAL PEPTIDE (HUMAN, BOVINE, PORCINE, RAT)
Vasoactive intestinal octacosapeptide (pig), 6-(4-chloro-D-phenylalanine)-17-L-leucine-
Vasoactive intestinal octacosapeptide (swine), 6-(4-chloro-D-phenylalanine)-17-L-leucine-
HIS-SER-ASP-ALA-VAL-(PCL)DPHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
HIS-SER-ASP-ALA-VAL-PCL-D-PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
H-HIS-SER-ASP-ALA-VAL-D-PHE(4-CL)-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
H-His-Ser-Asp-Ala-Val-p-chloro-D-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
HIS-SER-ASP-ALA-VAL-PCLDPHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-LEU-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2 [HSDAV-PCLDPHE-TDNYTRLRKQLAVKKYLNSILN-NH2]
L-His-L-Ser-L-Asp-L-Ala-L-Val-4-Chloro-D-Phe-L-Thr-L-Asp-L-Asn-L-Tyr-L-Thr-L-Arg-L-Leu-L-Arg-L-Lys-L-Gln-L-Leu-L-Ala-L-Val-L-Lys-L-Lys-L-Tyr-L-Leu-L-Asn-L-Ser-L-Ile-L-Leu-L-Asn-NH2
(p-Chloro-D-Phe6,Leu17)-VIP (human, mouse, rat) trifluoroacetate salt H-His-Ser-Asp-Ala-Val-p-chloro-D-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 trifluoroacetate salt | [Molecular Formula]
C148H239ClN44O42 | [MDL Number]
MFCD00133956 | [MOL File]
102805-45-8.mol | [Molecular Weight]
3342.2 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Powder | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
His-Ser-Asp-Ala-Val-{Cl-Phe}-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Leu-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
| Hazard Information | Back Directory | [Uses]
[D-p-Cl-Phe6,Leu17]-VIP is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP has no activity on glucagon, secretin or GRF receptors[1][2][3]. | [Biochem/physiol Actions]
VIP receptor antagonist | [storage]
Store at -20°C | [References]
[1] Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86. DOI:10.1016/s0014-2999(96)00966-1
[2] Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7. DOI:10.1152/ajpgi.1986.250.4.G553
[3] Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42. DOI:10.1152/ajpgi.1993.264.2.G237 |
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