| Identification | Back Directory | [Name]
5-CHLORO INDAZOLE-3-CARBOXALDEHYDE | [CAS]
102735-84-2 | [Synonyms]
5-Chloro-3-(1H)indazole
5-CHLORO INDAZOLE-3-CARBOXALDEHYDE
5-Chloro indazole-4-carboxaldehyde
5-chloro-2H-indazole-3-carbaldehyde
5-CHLORO-1H-INDAZOLE-3-CARBALDEHYDE
5-chloro-2H-indazole-3-carboxaldehyde
5-CHLORO-3-(1H)INDAZOLE CARBOXALDEHYDE
1H-Indazole-3-carboxaldehyde, 5-chloro-
5-Chloro-1H-indazole-3-carbaldehyde ,97% | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C8H5ClN2O | [MDL Number]
MFCD07781535 | [MOL File]
102735-84-2.mol | [Molecular Weight]
180.59 |
| Chemical Properties | Back Directory | [Boiling point ]
391.7±22.0 °C(Predicted) | [density ]
1.521±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
solid | [pka]
10.85±0.40(Predicted) | [color ]
Brown |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow solid | [Synthesis]
Step 3: Manganese dioxide (0.991 g, 11.4 mmol) was added to a solution of (5-chloro-1H-indazol-3-yl)methanol (0.208 g, 1.14 mmol) in ethyl acetate (10 mL) at room temperature. The reaction mixture was stirred overnight. Subsequently, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent: chloroform/methanol) to afford the target product 5-chloro-1H-indazole-3-carbaldehyde (0.106 g, 51% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 7.53 (dd, J = 2.2,8.8 Hz, 1H), 7.77 (d, J = 8.8 Hz, 1H), 8.11 (d, J = 2.2 Hz, 1H), 10.18 (s, 1H), 14.36 (br s, 1H). | [References]
[1] Journal of the American Chemical Society, 1986, vol. 108, # 14, p. 4115 - 4119
[2] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0359 |
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