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ChemicalBook--->CAS DataBase List--->1003000-59-6

1003000-59-6

1003000-59-6 Structure

1003000-59-6 Structure
IdentificationBack Directory
[Name]

NY0116
[CAS]

1003000-59-6
[Synonyms]

NY0116
Guanidine, N-[2-(triphenylmethoxy)ethyl]-
[Molecular Formula]

C22H23N3O
[MOL File]

1003000-59-6.mol
[Molecular Weight]

345.44
Chemical PropertiesBack Directory
[Boiling point ]

480.7±47.0 °C(Predicted)
[density ]

1.10±0.1 g/cm3(Predicted)
[pka]

12.67±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells[1].
[in vivo]

NY0116 (3-30 mg/kg; SC; ; for 14 days) decreases bodyweight, visceral adipose tissue, and cholesterol on a high‐fat diet[1].

Animal Model:Male diet induced obese (DIO) C57BL/6J mice age 18 weeks and 8 age[1]
Dosage:3, 10, 30 mg/kg
Administration:Subcutaneous injection; for 14 days
Result:Significantly decreased bodyweight compared to vehicle, whereas mice were maintained on a high-fat diet.
[References]

[1] Catherine M Sampson, et al. Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models. Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425. DOI:10.1002/prp2.425
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