| Identification | Back Directory | [Name]
C-(5-BROMO-THIOPHEN-2-YL)-METHYLAMINE HYDROCHLORIDE | [CAS]
1001414-56-7 | [Synonyms]
2-Aminomethyl-5-bromothiophenem, HBr
(5-bromothiophen-2-yl)methanamine HCl
(5-bromo-2-thienyl)methanamine hydrochloride
(5-BROMOTHIOPHEN-2-YL)METHANAMINE HYDROBROMIDE
(5-broMothiophen-2-yl)MethanaMine hydrochloride
C-(5-BROMO-THIOPHEN-2-YL)-METHYLAMINE HYDROCHLORIDE | [Molecular Formula]
C5H7BrClNS | [MDL Number]
MFCD08752581 | [MOL File]
1001414-56-7.mol | [Molecular Weight]
228.538 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C5H6BrNS.ClH/c6-5-2-1-4(3-7)8-5;/h1-2H,3,7H2;1H | [InChIKey]
DWYVWUCEDHIAMH-UHFFFAOYSA-N | [SMILES]
C(C1=CC=C(Br)S1)N.Cl |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of (5-bromothiophen-2-yl)methylamine hydrochloride from tert-butyl (5-bromothiophen-2-yl)methylcarbamate: tert-butyl (5-bromothiophen-2-yl)methylcarbamate (8.322 g, 0.0285 mmol) was dissolved in 150 mL of anhydrous ethyl acetate. After continuous passage of dry HCl gas for 2 h, a large amount of precipitate generation was observed. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was washed sequentially with anhydrous ethyl acetate (3 x 50 mL) and ether (3 x 50 mL) to give the final target product (5-bromothiophen-2-yl)methylamine hydrochloride (5.862 g) in 95% yield. | [References]
[1] Patent: WO2008/5457, 2008, A2. Location in patent: Page/Page column 185 |
|
|