| Identification | Back Directory | [Name]
BMS711939 | [CAS]
1000998-62-8 | [Synonyms]
BMS711939
N-(5-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)-2-fluorobenzyl)-n-(methoxycarbonyl)glycine
Glycine, N-[[5-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]-2-fluorophenyl]methyl]-N-(methoxycarbonyl)- | [Molecular Formula]
C22H20ClFN2O6 | [MDL Number]
MFCD31556555 | [MOL File]
1000998-62-8.mol | [Molecular Weight]
462.86 |
| Hazard Information | Back Directory | [Uses]
BMS711939 is a selective agonist for peroxisome proliferator-activated receptor α (PPAR α), with EC50 of 4 nM and 4.5 μM, for human PPARα and human PPARγ. BMS711939 exhibits good pharmacokinetic characters in rats models. BMS711939 increases HDL cholesterol, reduces LDL cholesterol and triglycerides[1]. | [IC 50]
hPPARα: 4 nM (IC50); hPPARγ: 4.5 μM (IC50) | [References]
[1] Shi Y, et al., Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. DOI:10.1021/acsmedchemlett.6b00033 |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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